Making content available to as many people as possible is a best practice. Consider this: It is very likely older users and users with disabilities represent a growing segment of your readership, and website accessibility litigation is up significantly. Providing an accessible path for your content is both good business and risk mitigation.
Our web reader interface is WCAG AA compliant. We enable the process by extracting accessible HTML from our client's PDF documents.
Here's a sample of how Apple's VoiceOver screen reader accesses the GTxcel web reader interface.